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Sunday, July 26, 2020 | History

2 edition of Studies on tryptophan load test and pyridoxine treatment in children with epilepsy. found in the catalog.

Studies on tryptophan load test and pyridoxine treatment in children with epilepsy.

Olle Hansson

Studies on tryptophan load test and pyridoxine treatment in children with epilepsy.

by Olle Hansson

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  • 10 Currently reading

Published by Universitet, Almqvist & Wiksell (Distr.) in Uppsala, Stockholm .
Written in English

    Subjects:
  • Vitamin B6 deficiency.,
  • Tryptophan -- Metabolism.,
  • Epilepsy in children.

  • Edition Notes

    SeriesActa Universitatis Upsaliensis., 48
    Classifications
    LC ClassificationsR85.U76 A26 no. 48
    The Physical Object
    Pagination11 p.
    Number of Pages11
    ID Numbers
    Open LibraryOL5662578M
    LC Control Number68111466

    College of General Practitioners, a survey of epilepsy in children under the age of 5 has been initiated. Research on infantile spasms is being continuied and other researches include a study of pyridoxine-dependent convulsions investigated by the tryptophan load test, an inquiry into convulsions precipitated by watching television, and. In two British neurologists, A. F. Heeley and G. E. Roberts, reported that 11 of 19 autistic children excreted abnormal metabolites in their urine when given a tryptophan load test. Giving these children a single 30 mg tablet of vitamin B6 normalized their urine; however, no behavioral studies were done.

    Bonavita, E. [Neuropsychological study of the senile brain during and after single and combined treatment with deanol and citicoline]. ;(5) View abstract. Abnormal tryptophan load tests in women taking high-dose oral contraceptives in the s and s suggested that these women were vitamin B6 deficient. Abnormal results in the tryptophan load test led a number of clinicians to prescribe high doses (– mg/day) of vitamin B6 to women in order to relieve depression and other side effects.

    In a review of earlier studies of men with various protein intakes, Linkswiler (89) concluded that normalisation of a tryptophan load test required mg vitamin B 6. Miller et al. (90) found that mg vitamin B 6 led to plasma PLP levels above 30 nmol/l for young men with various protein intakes. Plasma and erythrocyte transaminase activity in most instances reflects pyridoxine status of fish although high tryptophan load in the diet tends to increase the pyridoxine requirement. Liver storage measured by microbiological assay showed V-g of pyridoxine activity/g in fresh sea salmon liver; whereas, fingerling salmon fed a 50 percent.


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Studies on tryptophan load test and pyridoxine treatment in children with epilepsy by Olle Hansson Download PDF EPUB FB2

In all of 7 with increased and 7 with normal h excretion of 3HK, the ratio of 3HAA to 3HK excretion during the first 4 h after tryptophan was normal, indicating normal kynureninase activity.

Five children who responded clinically to treatment with pyridoxine pyridoxine Subject Category: Chemicals and Chemical GroupsCited by: 2. Studies on tryptophan load test and pyridoxine treatment in children with epilepsy Hansson, Olle Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine.

Acta Neurol Scand. ;Suppl Tryptophan load test and pyridoxine treatment in epileptic children. Hansson O. PMID: [PubMed - indexed for MEDLINE]Author: Olle Hansson. This suggests that ACTH may improve the patient through increasing pyridoxine availability to the brain.

The results of systemic pyridoxine administration to 3 patients show that there is no true. Of the patients with a normal tryptophan load test, none responded to pyridoxine34, Of children (ages years) with epilepsy associated with impaired intellectual development, progressive emotional disturbances, and abnormal EEGs, all excreted elevated amounts of xanthurenic acid after a tryptophan load.

After administration of mg. Hagberg B, Hamfelt A, Hansson O. Tryptophan load tests and pyridoxalphosphate levels in epileptic children. Non-progressive brain damage and degenerative brain by: 5.

vitamin E is relatively safe and may be considered for adjunctive treatment in epileptic patients, particularly children. Vitamin K: The incidence of vitamin K deficiency is incr eased in Author: Mohammad Asif.

Kynurenine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid and xanthurenic acid were isolated by column chromatography and estimated in urine after tryptophan load in a group of children with phenylketonuria aged from 1 month to 10 years.

The children received either a normal diet or a diet low in phenylalanine, with or without extra by: Urinary parameters of pyridoxal-phosphate (PLP)-dependent tryptophan degradation and the level of 4-pyridoxic acid, the end product of pyridoxine metabolism, were measured by HPLC method with simultaneous ultraviolet and fluorimetric detection in children with different forms of epilepsy and matched healthy by: 3.

Abstract. The amino acid tryptophan was first isolated as the chromogenic substance in tryptic digests of proteins (1). Since that time, naturally occurring L-tryptophan has been shown to be one of the indispensable amino acids having a number of important biological by: In epileptic children, it would also expiain the discrepancy between the high frequency of abnormal tryptophan load tests and the infrequency of improvement on l7 pyridoxine treatment.2, 6 * Besides the well-known syndromes of â pyridoxine deficiencyâ and â pyridoxine dependencyâ in infancy, however, a response to pyridoxine is reported in.

Hughes PA, Bower BD, Raine DN, Syed N. Metabolism of tryptophan in childhood epilepsy. Arch Dis Child. Dec; 41 ()– [PMC free article] HUNT AD, Jr, STOKES J, Jr, McCRORY WW, STROUD HH. Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine.

Pediatrics. Feb; 13 (2)– Effect ofTreatment onthe Metabolism ofTryptophan in Childhood Epilepsy P. HUGHES, B. BOWER*, D. RAINE, and N. SYED Fromthe Biochemistry Department, Children's Hospital, Birmingham16, and Department ofPaediatrics andChildHealth, University ofBirmingham Ina previous paper (Hughes, Bower, Raine, and Syed, ) it was shown that about Cited by: 5.

Increased urinary excretion of xanthurenic acid and related intermediary metabolites following tryptophan loading is considered one of the most sensitive indicators of pyridoxine deficiency.

Seizures or epilepsy associated with Vitamin B 6 dependencyCited by:   Conversion of tryptophan to niacin relies on pyridoxine-dependent enzymes.

A tryptophan load of mg/kg is administered, and the urinary excretion of tryptophan metabolites is measured. High excretion of kynurenine, kynurenic acid, and xanthurenic acid indicates a functional deficiency in pyridoxine-dependent enzymes. This test is influenced by protein intake. some subclinical pyridoxine deficiency in children receiving isoniazid.

20•21 Although previous studies have used the tryptophan test and relied upon excretion of xanthurenic acid, a test not correlated with clinical pyridoxine deficiency, 10 it was elected in this study to use a microbiologic assay.

This is a superior method because the. The results, however, were negative even when an abnormal tryptophan load test had been found.

Kamiishi et al. gave vitamin B6 in a randomized comparative study acutely to children who in a febrile episode had had a FC.

“Some” patients had also received Cited by: LETTERS TO THE EDITOR In our initial paper (Hagberg et al. ) on tryptophan loading in children with epilepsy, there was an over-representation of cases with a so-called â abnormalâ test among cases with cryptogenic epilepsy. Metabolism ofTryptophanin Childhood Epilepsy P.

BOWER,D. RAINE,andN. SYED Fromthe Biochemistry Department, Birmingham Children's Hospital, Birming and DepartmentofPaediatrics andChildHealth, University ofBirmingham A relation between pyridoxine and convulsive phenomenahas been established over several yearsCited by: Click on the title to browse this issue.

Hansson O. Tryptophan loading and pyridoxine treatment in children with epilepsy. Ann NY Acad Sci ;–9. Hughes PAM, Bower BD, Raine DN, Syed N. Metabolism of tryptophan in childhood epilepsy. Arch Dis Child ;–   Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene ALDH7A1 leading to recurrent neonatal seizures, which are uniquely alleviated by high doses of pyridoxine or pyridoxal 5′-phosphate (vitamin B6 vitamers).

Despite treatment, neurodevelopmental disabilities are still observed in most PDE patients underlining the Cited by: studies, butwithout being given pyridoxine. Ofthese six control patients, twoweresubsequently given a6-month course of pyridoxine mg.

daily, and the clinical assessment of the severity of the neuropathy and the L-tryptophan load test were repeated at the end of the ,attheendofthestudy,Cited by: 6.